Medicine and Product Research

전문 분야

신경 유전학, 신경 근육 전염의 분자 메커니즘

Career Summary

• 1977-1983
  Nagoya University School of Medicine, Japan
• 1983-1985
  Internship in Internal Medicine, Nagoya National Hospital, Japan
• 1985-1988
  Residency and Staff in Neurology, Nagoya National Hospital, Japan
• 1988-1992
  Nagoya University Graduate School of Medicine, Japan
• 1992-1993
  JSPS (Japanese Society for Promotion of Science) Research Fellow,Department of Biomedical Chemistry, Nagoya University School of Medicine, Japan
• 1993-1995
  Research Fellow, Department of Neurology, Mayo Clinic, USA
• 1996-1998
  Research Associate, Department of Neurology, Mayo Clinic, USA
• 1998-2004
  Assistant Professor, Mayo Medical School, USA
• 2004-present
  Professor, Division of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Japan
• 2009-present
  Vice Dean, Nagoya University Graduate School of Medicine

Research Theme

• Molecular pathomechanisms and the regulations of defective neuromuscular transmission defects
• Physiology, pathology, and regulations of RNA metabolisms
• Drug repositioning strategy for orphan diseases
• Biological bases of the disease-preventing effects of molecular hydrogen

Original Articles

• Fu Y, Ito M, Fujita Y, Ito M, Ichihara M, Masuda A, Suzuki Y, Maesawa S, Kajita Y, Hirayama M, Ohsawa I, Ohta S, Ohno K. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson’s disease. Neurosci Lett 2009, 453: 81–85.
• Itoh T, Fujita Y, Ito M, Masuda A, Ohno K, Ichihara M, Kojima T, Nozawa Y, Ito M. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun 2009, 389: 651-656.
• Itoh T, Hamada N, Terazawa R, Ito M, Ohno K, Ichihara M, Nozawa Y, Ito M. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun 2011, 411:143-149.
• Ito M*, Ibi T*, Sahashi K, Ichihara M, Ito M, Ohno K. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Med Gas Res 2011, 1:24. *Equal contribution.
• Ito M, Hirayama M, Yamai K, Goto S, Ichihara M, Ohno K. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson’s disease in rats. Med Gas Res 2012, 2:15.
• Iio A, Ito M, Itoh T, Terazawa R, Fujita Y, Nozawa Y, Ohsawa I, Ohno K, Ito M. Molecular hydrogen attenuates fatty acid uptake and lipid accumulation through downregulating cd36 expression in HepG2 cells. Med Gas Res 2013, 3: 6.
• Mano Y, Kotani T, Ito M, Nagai T, Ichinohashi Y, Yamada K, Ohno K, Kikkawa F, Toyokuni S. Maternal molecular hydrogen administration ameliorates rat fetal hippocampal damage caused by in utero ischemia-reperfusion. Free Radic Biol Med 2014, 69: 324-330.
• Sobue S, Yamai K, Ito M, Ohno K, Ito M, Iwamoto T, Qiao S, Ohkuwa T. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem, in press

Reviews

• Ohta S, Nakao A, Ohno K. The 2011 Medical Molecular Hydrogen Symposium: An Inaugural Symposium of the Journal Medical Gas Research. Medical Gas Research 2011, 1:10.
• Ohno K, Ito M, Ichihara M, and Ito M. Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases. Oxid Med Cell Longev. 2012, Article ID 353152.
• Noda M, Fujita K, Ohsawa I, Ito M, Ohno K. Multiple effects of molecular hydrogen and its distinct mechanism. J Neurol Disord 2014, 2: 6
• Noda M, Ito M, Ohsawa I, Ohno K. Beneficial effects of hydrogen in the cns and a new brain-stomach interaction. Eur J Neurodeg Dis, in press
• Invited Presentations at Scientific Meetings (in English)
• Ohno K Molecular Hydrogen as an Antioxidant – Review and our experience – University of Fukui Biomedical Imaging Research Center Research seminar, Fukui, Japan. Feb 2, 2009
• Ohno K, Molecular hydrogen on oxidative stress diseases in nervous system. 36th Annual Meeting of the Japan Neuroscience Society, Kyoto, Japan. Jun 20, 2013

Career Summary

• 1970-1974
  Department of Chemistry, Faculty of Science, Tokyo University, Japan
• 1974-1979
  Graduate School of Pharmaceutical Sciences, Tokyo University, Japan.
• 1979 -1981
  Research associate in Gunma University Graduate School of Medicine, Japan
• 1981-1985
  Research Associate, Biocenter, University of Basel, Switzerland.
• 1985-1994
  Lecture and Associate Professor of Biochemistry, Jichi Medical School, Japan
• 1994-present
  Professor, Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nippon Medical School, Japan.

Research Theme

• Molecular mechanism on hydrogen medicine.
• Drug discovery on mitochondrial diseases.
• Visualization and real-time monitoring of oxidative stress.

Selected Hydrogen Studies

• (1)
  Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.
  Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S, Ohta S.
  Nat Med. 2007 Jun;13(6):688-94. Epub 2007 May 7
• (2)
  Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.
  Nagata K, Nakashima-Kamimura N, Mikami T, Ohsawa I, Ohta S.
  Neuropsychopharmacology. 2009 Jan;34(2):501-8. doi: 10.1038/npp.2008.95. Epub 2008 Jun 18.
• (3)
  Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice.
  Kamimura N, Nishimaki K, Ohsawa I, Ohta S.
  Obesity (Silver Spring). 2011 Jul;19(7):1396-403. doi: 10.1038/oby.2011.6. Epub 2011 Feb 3.
• (4)
  Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine.
  Ohta S.
  Pharmacol Ther. 2014 Oct;144(1):1-11. doi: 10.1016/j.pharmthera.2014.04.006. Epub 2014 Apr 24.
• (5)
  Hydrogen inhalation during normoxic resuscitation improves neurological outcome in a rat model of cardiac arrest independently of targeted temperature management.
  Hayashida K, Sano M, Kamimura N, Yokota T, Suzuki M, Ohta S, Fukuda K, Hori S.
  Circulation. 2014 Dec 9;130(24):2173-80. doi: 10.1161/CIRCULATIONAHA.114.011848. Epub 2014 Nov 3.

Selected Additional Studies

• (1)
  Real-time monitoring of oxidative stress in live mouse skin.
  Wolf AM, Nishimaki K, Kamimura N, Ohta S.
  J Invest Dermatol. 2014 Jun;134(6):1701-9. doi: 10.1038/jid.2013.
  428. Epub 2013 Oct 15.
• (2)
  Taurine ameliorates impaired the mitochondrial function and prevents stroke-like episodes in patients with MELAS.
  Rikimaru M, Ohsawa Y, Wolf AM, Nishimaki K, Ichimiya H, Kamimura N, Nishimatsu S, Ohta S, Sunada Y.
  Intern Med. 2012;51(24):3351-7. Epub 2012 Dec 15.
• (3)
  Positive contribution of pathogenic mutations in the mitochondrial genome to the promotion of cancer by prevention from apoptosis.
  Shidara Y, Yamagata K, Kanamori T, Nakano K, Kwong JQ, Manfredi G, Oda H, Ohta S.
  Cancer Res. 2005 Mar 1;65(5):1655-63.
• (4)
  Age-dependent neurodegeneration accompanying memory loss in transgenic mice defective in mitochondrial aldehyde dehydrogenase 2 activity.
  Ohsawa I, Nishimaki K, Murakami Y, Suzuki Y, Ishikawa M, Ohta S.
  J Neurosci. 2008 Jun 11;28(24):6239-49. doi: 10.1523/JNEUROSCI.4956-07.2008.
• (5)
  Protection against ischemic brain injury by protein therapeutics.
  Asoh S, Ohsawa I, Mori T, Katsura K, Hiraide T, Katayama Y, Kimura M, Ozaki D, Yamagata K, Ohta S.
  Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):17107-12. Epub 2002 Dec 10.

Career Summary

• 1936년 10월 20일, Zhong Nanshan은 Nanjing에서 태어났습니다. [1] 그의 아버지 Zhong Shifan은 중국에서 유명한 소아과 의사였으며 그의 어머니 Liao Yueqin은 Guangdong Cancer Hospital의 설립자 중 한 사람이었습니다. 출처: 바이두
• 1953년에는 화남사범대학부속고등학교(화남사범대학 부속고등학교) 수학.
• 1960년에 베이징 의과대학(현 북경대학 의과대학)을 졸업
• 1960년 7월부터 1971년 8월까지 북경 의과대학(현 북경대학 의과대학) 방사선의학 교수 연구단 조교수 재직.
• 1971년 9월부터 1974년 4월까지 광저우 의과대학 제1부속병원 내과 레지던트를 역임
• 1974년 4월부터 1978년 8월까지 광저우 의과대학 제1부속병원 내과에서 주치의 역임.
• 1978년 9월부터 1982년 12월까지 광저우 의과대학 제1부속병원 내과 부주임의 및 강사 역임.
• 1979년부터 1981년까지 에든버러 대학교 의과 대학과 런던 대학교 호흡기과 수학
• 1983년 1월부터 1986년 12월까지 광저우 의과대학 부교수(1985년 이후 중앙선도건강의사로 임명) 역임.
• 1986년 12월부터 1995년까지 광저우 의과대학 호흡기의학과 교수 및 석사 지도교수 재직.
• 1987년 12월부터 1992년 10월까지 광저우 의과대학 제1부속병원 원장 역임.
• 1992년 5월부터 2002년 12월까지 Zhong Nanshan은 광저우 의과대학 학장 및 당 서기를 역임
• 1995년 8월 북경대학교 보건과학센터 호흡기내과 교수 및 박사과정 지도교수 재직
• 1995년 10월부터 1996년 10월까지 중국정부 캐나다 몬트리올 McGill University방문 연구원을 파견.
• 1996년 5월, 그는 중국 공학 아카데미 학자 선출
• 1997년 12월부터 1999년 12월까지 광저우 의과대학 제1부속병원 광저우호흡기질환연구소 주임의사.
• 1999년 12월부터 2012년 10월까지, 광저우 의과대학 제1부속병원 광저우 호흡기 질환 연구소 교수/부소장.
• 1998년 6월에는 중국 공과대학 의학 및 보건공학과 부국장 역임. [59]
• 2003년 사스(SARS)가 발생하고 중난산(Zhong Nanshan)을 대표하는 의료 종사자들이 장기간의 노력으로 사스(SARS)에 예방,치료
• 2004년에는 "움직이는 중국 2003" 10인 중 한 명으로 선정
• 2005년 4월 13일 중국 의사협회 제23대 회장 선출.
• 2007년에는 University of Edinburgh에서 명예 박사 학위
• 2007년 10월에는 국립 호흡기 질환 연구소 소장 역임
• 2009년 7월에는 구이저우 의과대학 명예 학장을 역임
• 2009년 9월 10일, 중난산 "신중국 건국 이후 중국인 100인" 중 한 명으로 선정
• 2010년에는 마카오 과학 기술 대학교 명예 박사 학위 수여
• 2012년 10월부터 2013년 7월까지 광저우 의과대학 제1부속병원 광저우호흡기질환연구소 교수/부원장 역임.
• 2014년 홍콩중문대학교 명예 이학박사 학위 수여
• 2020년 1월 20일, 국가위생건강위원회 고위급 전문가 그룹은 Zhong Nanshan을 전문가 그룹의 지도자로 하는 기자 회견 개최
• 2020년 1월 21일 신종 코로나바이러스 공동 예방 및 통제 작업 메커니즘 과학 연구 팀의 첫 번째 회의에서 Zhong Nanshan이 팀장으로 임명
• 2020년 9월 3일 WHO 신종 코로나바이러스 감염증 대응 전문가 그룹 공동 의장은 회원국 브리핑에서 전문가 그룹 회원 명단을 발표했고, Zhong Nanshan 선출 제11기, 12기 전국인민대표대회 대표, 중국인민정치협상회의 제8기, 제9기, 제10기 전국인민대표대회 위원
• 2021년 4월 6일, 샤먼 대학교는 Zhong Nanshan 학자를 우수 방문 교수로 임명.
• 2021년 11월, 비상관리부 소방구조국의 초청으로 "공화국 메달"을 수상한 중국 공과대학 학자인 Zhong Nanshan이 "중국 화재 선전 공익 사절" 역임
• 2021년 7월 27일, 선전 인민 병원은 호흡기 질환 연구소 명예 이사로 Zhong Nanshan 학자 임명

연구 분야

• 천식, 만성폐쇄성폐질환, 호흡부전 및 호흡기계, 호흡기중환자 치료에 분자수소흡입치료 임상시험에 대한 감독을 했습니다.
• 2010년 9월 현재 Zhong Nanshan은 중국 및 외국 의학 저널에 150편 이상의 논문을 발표했으며 그 중 국제적으로 SCI에서 81회 인용되었습니다. ", "천식", "현대 호흡기 질환 진행" 및 "해석"

Career Summary

• 1979-1981
  Assistant professor, Department of Physiology, Faculty of Medicine, Kyushu University, Japan
• 1986-1990
  Postdoctoral Fellow, Department of Cardiac Physiology, The Rockefeller University, New York, USA.
• 1990 -1996
  Research Fellow, Department of Medical Biophsysics, Kanazawa University, School of Medicine, Japan
• 1996-1999
  Assistant Professor, Department of Physiology, Faculty of Medicine, Kyushu University, Japan
• 1999-present
  Associate Professor, Laboratory of Pathophysiology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan

Academic Degree

• 1986.07.23: PhD, Kyoto University Medical School: Pharmacology, “Effects of goniopora toxin on membrane currents of bullfrog atrium”

Membership in Academic Societies

• 1. Society for Neuroscience (SfN) (USA): Member of Professional Development Committee (2011-2014)
• 2. Japanese Society of Pathophysiology: Member of Council (2006~), Member of Trustee (2007~),
• 3. The Physiological Society of Japan: Member of Council
• 4. The Japanese Society for Neurochemistry: Member of Council, Member of Diversity Committee (2013~, Chair; 2015~), Member of Promoting Brain Science Committee (2011-2013)
• 5. The Japan Neuroscience Society: Member of International Affair committee (2014~), Member of Program Committee for Neuro2016 and Neuro2017
• 6. Society for Molecular Hydrogen Medical and Biology: Member of a Steering Committee
• 7. Women in Physiology of Japan: Editorial Committee Member (2010~)
• 8. The Pharmaceutical Society of Japan
• 9. Japanese Cancer Association

Editorial Board Membership

• 1. Glia (2010 - )
• 2. Journal of Molecular Neuroscicnce (2012~)
• 3. Advances in Neuroimmune Biology (2013~)
• 4. Advances in Neuroimmune Biology, Chief Editor of a special issue “Dysfunction of Glial Cells in Neurological and Psychological Disorders: From Bench to Bedside (2016)

Patents

• Novel medicament for ameliorating neurotransmission dysfunction diseases. Juridical Foundation, No. 03812336.0-2107-JP0315227, Date; 06.10.06

Selected Hydrogen Publications

• 1. Fujita K, Seike T, Yutsudo N, Ohno M, Yamada H, Yamaguchi H, Sakumi K, Yamakawa Y, Kido MA, Takaki A, Katafuchi T, Tanaka Y, Nakabeppu Y, Noda M.?Hydrogen in drinking water reduces dopaminergic neuronal loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. PLoS One. Sep 30;4(9):e7247 (2009)
• 2. Matsumoto A, Yamafuji M, Tachibana T, Nakabeppu Y, Noda M, Nakaya H. Oral ‘hydrogen water’ induces neuroprotective ghrelin secretion in mice. Sci Rep. 3:3273. doi: 10.1038/srep03273. (2013)
• 3. Mami Noda, Ikuroh Ohsawa, Masafumi Ito and Kinji Ohno. Beneficial effects of hydrogen in the CNS and a new brain-stomach interaction. European Journal of Neurodegenerative Diseases 3(1): 25-34 (2014)
• 4. Mami Noda, Kyota Fujita, Ikuroh Ohsawa, Masafumi Ito and Kinji Ohno. Multiple Effects of Molecular Hydrogen and its Distinct Mechanism. Journal of Neurolog Disorders 2014, 2:6, http://dx.doi.org/10.4172/2329-6895.1000189 (2014)
• 5. Fujita K, Nakabeppu Y, Noda M. Therapeutic effects of hydrogen in animal models of Parkinson’s disease. Special issue: Animal Model of Parkinson’s Disease, Parkinson’s Disease, vol. 2011, Article ID 307875, 9 pages, 2011. doi:10.4061/2011/307875 (2011)

PUBLICATIONS : Original Articles

• 1. Noda M, Yuki Mori, Yusaku Yoshioka. Sex- and age-dependent effects of thyroid hormone on glial morphology and function. Opera Medica et Physiologica (OM&P) 2, 85-92 (2016)
• 2. Zeidán-Chuliá F, de Oliveira BN, Casanova MF, Casanova EL, Noda M, Salmina AB, Verkhratsky A.. Up-regulation of Oligodendrocyte Lineage Markers in the Cerebellum of Autistic Patients: Evidence from Network Analysis of Gene Expression. Molecular Neurobiology l 53:4019–4025 DOI: 10.1007/s12035-015-9351-7 (2016)
• 3. Noda M, Kobayashi A. Nicotine inhibits activation of microglial proton currents via interactions with ?7 acetylcholine receptors. J Physiol Sci. 2016 Jun 2. [Epub ahead of print]

Reviews

• 1. Noda M. Mechanisms of nicotine-induced neuroprotection: Inhibition of NADPH oxidase and subsequent proton channel activation by stimulating ?7 nicotinic acetylcholine receptor in activated microglia. Advances in Neuroimmune Biology, 6 (2015/2016) 107–115, DOI 10.3233/NIB-160119 (2016)
• 2. Noda M.?Dysfunction of glutamate receptors in microglia may cause neurodegeneration. Curr Alzheimer Res. 2016;13(4):381-386.
• 3. Noda M. Possible role of glial cells in the relationship between thyroid dysfunction and mental disorders. Front. Cell. Neurosci. Jun 3;9:194.?doi: 10.3389/fncel.2015.00194 (2015)

Book chapters

• 1. Verkhratsky A., Noda M. and Parpura V. Microglia: Structure and Function. In: Brain Mapping: An Encyclopedic Reference, vol. 2, pp. 109-113. Arthur W. Toga (ed), Academic Press: Elsevier (2015)
• 2. Alexei Verkhratsky & Mami Noda, General Physiology and Pathophysiology of Microglia, in “Neuroinfl ammation and Neurodegeneration”, p47-60, DOI 10.1007/978-1-4939-1071-7_3, P.K. Peterson and M. Toborek (eds.), Springer Science+Business Media New York (2014)
• 3. Mami Noda, Chapter 13. Possible therapeutic targets in microglia, in “Pathological Potential of Neuroglia: Possible New Targets for Medical Intervention”, p293-313, Vladimir Parpura and Alexei Verkhratsky (eds), Boston, MA: Springer (2014)

Conferences

• 1. Mami Noda, Effects of thyroid hormones in neuron-glia interaction and their sex- and age-dependency. (St.Petersburg, Russia, 2016.12.13) workshop «The results and perspectives of common investigations of Kyushu University (Fukuoka, Japan) and FSBSI «IEM» (Saint-Petersburg, Russia)»
• 2. Mami Noda, Yusaku Yoshioka, Yosuke Kitahara, Akinori Nishi. Thyroid hormone and glioendocrine system in neurological and psychiatric dysfunctions. (Suzhou, China, 2016.12.05-09(09)) Cold Spring Harbor Asia – Novel Insights into Glia Function and Dysfunction
• 3. Mami Noda, The latest research trends of hydrogen in Japan – Neuroprotective effects of molecular hydrogen and involvement of stomach-brain interaction. (Seoul, Korea, 2016.11.25) 2016 Korea International Symposium on Hydrogen

Seminars and lectures

• 1. Noda, M. Neuroprotective effects of molecular hydrogen; Innovation by a new medical gas (Guangxi University Hospital of Chinese Medicine, Guangxi, China, 2016. 07.10-14(14))
• 2. Noda, M. Physiology of microglia. (Guangxi University of Chinese Medicine, Guangxi, China, 2016. 07.10-14(14))
• 3. Noda, M. The role of thyroid hormon in microglial function. (MDC, Berlin, Germany, 2014. 07.15)

Oral sessions

• 1. Mami Noda. Thyroid dysfunction and glial cells: possible contribution to neurological dysfunctions. (Tokyo, Japan, 2015.09.03-05 (04)) The 3rd Asian Clinical Congress (ACC3) in Tokyo.
• 2. Mami Noda, Kyota Fujita, Margaret A. Hamner, Megumi Yamafuji, Yoshinori Tanaka, Yusaku Nakabeppu, Bruce R. Ransom. ROLE OF OLIGODENDROCYTES IN THE PROTECTIVE EFFECTS OF MOLECULAR HYDROGEN AGAINST WHITE MATTER ISCHEMIC INJURY. (Merida, Mexico, 2013. 04.17-20 (20)) ISN (International Society for Neurochemistry, American Society for Neurochemistry) 24th Biennial Joint Meeting, Glial Sattelite
• 3. Kaoru Beppu, Taiki Miyamoto, Yuko Okuno, Mami Noda, Dysfunction of AMPA type of glutamate receptors in microglia and pathophysiological implication.. All Russian Students’ seminar for Fundamental Science and Clinical Medicine. (2009) (St. Petersburg, Russia, 2009.4.18)

Panels

• 1. Mami Noda, Ai Kobayashi. Neuroprotective effect of nicotine by inhibition of microglial proton currents via ?7 nAChRSociety for Neuroscience, (San Diego, USA, 2016.11.12-16 (12)) 46th Annual Meeting. 37.18
• 2. Mami Noda, Chieri Higashi, Jiadai Liu. Neuroprotective effect of molecular hydrogen in diabetic mouse model. (Copenhagen, Denmark, 2016.07.02-06(03), 10th FENS Forum of Neuroscience)
• 3. Jiadai Liu, Mami Noda. Protective effect of Na-DNA on pressure ulcer and elucidation of its mechanism. (Bangkok, Thailand, 2015.11.22-25) 8th FOAPS Congress)

전문 분야

미토콘드리아 변성과 노화, 신경퇴행성 질환 및 대사증후군에 대한 치료적 개입

Career Summary

• 2011-     
  Professor, School of Life Science and Technology, Xi’an Jiaotong Universn, China
• 2009-2011
  Associate Professor, School of Life Science and Technology, Xi’an University, Xi’an, China
• 2008 -2009
  Postdoctoral fellow, Banner (Sun) search Institute, AZ, USA
• 2006-2008
  Postdoctoral fellow, Institute for Brain Aging and Dementia, University of California, Irvine , CA, and Children’s Hospital Oearch Institute, CA, USA

Research publication

• 1. Hu R, Diao J, Li J, Tang Z, Li X, Leitz J, Long J, Liu J, Yu D, Zhao Q. (2016) Intrinsic and membrane-facilitated ?-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep. [Epub ahead of print] IF 5.578
• 2. Wang P, Jia L, Chen B, Zhang L, Liu J, Long J*, Li Y. (2016) Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock. [Epub ahead of print] IF 3.045
• 3. Huang H, Yang L, Zhang P, Qiu K, Huang J, Chen Y, Diao J, Liu J, Ji L, Long J*, Chao H*. (2016) Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. Biomaterials. IF 8.557
• 4. Hou C, Wang Y, Zhu E, Yan C, Zhao L, Wang X, Qiu Y, Shen H, Sun X, Feng Z, Liu J*, Long J*.(2016) Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer.Biochem Pharmacol. IF 5.009
• 5. Liu J, Peng Y, Wang X, Fan Y, Qin C, Shi L, Tang Y, Cao K, Li H, Long J*, Liu J*. (2016) Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. Mol Pharm. 13(1):73-84. IF 4.384
• 6. Tang Y, Peng Y, Liu J, Shi L, Wang Y, Long J*, Liu J*. (2015) Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer’s disease. J Neurochem. [Epub ahead of print] IF 4.281
• 7. Tang Y, Liu J, Long J*. (2015) Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig 3, 250-5. IF 1.8
• 8. Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J, Feng Z.(2015)Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr, 111667-76. IF 3.453
• 9. Sun L, Liu T, Li H, Yang L, Meng L, Lu Q, Long J.(2015) Fluorescent and cross-linked organic-inorganic hybrid nanoshells for monitoring drug delivery. ACS Appl Mater Interfaces 8, 4990-7.IF 6.723
• 10. Luo C, Li Y, Yang L, Zheng Y, Long J, Jia J, Xiao S, Liu J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.Int J Nanomedicine 9,4763-72. IF 4.383

EDUCATIONAL QUALIFICATIONS:

• M.D. 1963 Medicine Comenius Univ., Bratislava, Czechoslovakia
• Ph.D. 1968 Anatomy, Histology, Embryology Comenius Univ., Bratislava, Czechoslovakia
• D.Sc. 1984 Functional Morphology Univ. Safarik Kosice, Czechoslovakia
• Assoc. Prof. 1990 Physiology Comenius Univ., Bratislava, Czechoslovakia
• Full Professor 1996 Physiology Comenius Univ., Bratislava, Czechoslovakia
• Fellow of IACS 2002 Cardiology Canada

PROFESSIONAL EXPERIENCE:

• 2010-     
  Vice-director Slovak Medical University in Bratislava
• 2008       
  D.h.c., University of Zilina
• 1998 -2009
  elected member of 5 Academies ( SAS, SAV,working group of ALLEA, EASA, IACS, Russian Academy of Natural Sciences – foreign member)
• 1998-2009
  The First Vice-president of Slovak Academy of Sciences, Slovak Academy of Sciences,Štefánikova 49, 814 38 Bratislava 1, Slovak Republic
• 1988-1998
  Director of the Institute and Professor of Physiology Institute for Heart Research, Slovak Academy of Sciences, Bratislava, Czechoslovakia;
  Institute of Physiology, Faculty of Medicine, Comenius University, Bratislava, Czechoslovakia
• 1988-1990
  Interruptively Visiting Professor Center of Cardiovasc. Research, Manitoba, Univ. Winnipeg, Canada
• 1991-2011
  President Slovak League for Prevention and Treatment of Cardiovascular Diseases: “Heart to Heart”
• 1978-1988
  Deputy Director of the Institute of Exptl. Surgery., Slovak Academy of Science, Bratislava, Czechoslovakia
• 1968-1990
  Department of Morphology Head, Lecturer, Associate Professor Dept. of Morphology, Inst. Exptl. Surg., Slovak Academy of Sciences, Institute of Physiology and Institute of Anatomy, Faculty of Medicine, Bratislava, Czechoslovakia
• 1984-1987
  D.Sc. Univ. Safarik, Kosice, Czechoslovakia
• 1979-1986
  Interruptively Visiting Professor Dept. of Cardiothoracic Surgery and Dept. of Pathology, Mount Sinai School of Medicine, New York, USA
• 1970-1972
  Visiting Scientist Department of Anatomy, University of California, Los Angeles, USA
• 1968-     
  Ph.D. Head, Dept. of Morphology, Inst. Exptl. Surg., Slovak Academy of Sciences, Bratislava, Czechoslovakia

TEACHING SPECIALTIES:

• Morphology,Histochemistry, Electron Microscopy, Physiology, Pathophysiology, Experimental and/or Molecular Cardiology

MAJOR RESEARCH INTERESTS:

• Since 1971 has been primarily involved in a national cardiovascular research projects, and has been carrying out research into experimental and/or molecular cardiology. He has been involved in basic academic research problems, such as artificial circulation and heart transplantation with special emphasis on the study of histochemical, cytochemical, immunocytochemical and ultrastructural changes in the myocardium under various experimental conditions e.g. ischemia and reperfusion injury, calcium paradox, adaptation of the myocardium to ischemia, efect of radiation on cardivascular system and prevention of its adverse effect, molecular hydrogen effect and treatment etc.

HONORS AND AWARDS:

total more than 57 awards (selected):

• Gold Medal of Slovak Academy of Sciences (2005)
• 1st price of Academy of Education for popularization of science (2005)
• Gold Medal of University of Constantine Philoshopher for Scientific Achievements in Medical Sciences (2006).
• President of Slovakia – State Award of Slovak Republic – 1st Class ?udovít Štúr Order (2006)
• Doctor Honoris Causa (Dr.h.c.) – Žilina University 2008
• Award of the Minister of Education: Great Medal of Mikovíni for lifetime achievement in science and technology

Foreign:

• Medal of Merit, Institute of Cardiovascular Sciences, ISHR (2001)
• Honorary Citizen of the city of Winnipeg – Canada (2001)
• Award of International Academy of Cardiovascular Sciences “Norman Alpert Award for Established Investigators in Cardiovascular Sciences” (2002)
• Fellow of International Academy of Cardiovascular Sciences (2002)
• Vincenzo Panagia Distiguished Lecturer Award of International Academy of Cardiovascular Sciences 2011
• Distinquished leadership award in cardiovascular sciences – International Academy of Cardiovascular Sciences Canada 2014
• Naranjan Dhalla Award for innovative investigators in Cardiovascular Sciences. IACS 2015
• Medal for outstanding contributions to the IACS, ES IACS 2015

PUBLICATIONS:

• Total number of papers is over 550, full length publications 332 (In Journals 296, In Books, Text books and Proceedings 36). Total number of abstracts and short papers published – over 490.

MEMBERSHIP IN PROFESSIONAL SOCIETIES:

• International Society for Heart Research (council member till 2001)
• European Section of International Society for Heart Research (council member till 1999)
• Slovak Histochemical and Cytochemical Society (President from 1990-2000)
• Slovak Surgical Society
• Slovak League for Prevention and Treatment of Cardiovascular Diseases –President from 1991
• Czechoslovak Society of Electron Microscopy (council member from 1970 to 2001)
• Slovak Physiological Society (council member)
• Czechoslovak Society of Clinical and Theoretical Cardiology (council member till 1997)
• Slovak Cardiological Society (council member till 2001, honorary member)
• International Federation of Cardiological Societies (member) World Heart Federation member
• European Heart Network member
• International Federation of Histo and Cytochemical Societies (council member )
• Heart Friends Around the World (council member)
• International Academy of Cardiovascular Sciences ( board of directors and Fellow )
• ALLEA member (working group)
• European Academies Scientific Advisory Council member and member of WG
• European Academy of Sciences and Arts (Salzburg-Vienna) member of academy
• Learned Society of SAS- member of academy
• Slovak Learned Society member of academy
• Russian Academy of Natural Sciences – foreign member of academy

OTHER PROFESSIONAL ACTIVITIES:

• Editorial activities: editorial board of:
• Current Research – Cardiology
• Functional and Developmental Morphology (till 1994)
• Editorial board of BLL
• The Histochemical Journal from 1988
• Heart News and Views (till 1999)
• Clinical and Experimental Cardiology
• Canadian Journal of Cardiology
• Canadian Journal of Physiology and Pharmacology
• General Physiology and Biophysics (Field Editor)
• Acta Mechanica Slovaca Asoc.editor
• Teaching medical and postdoctoral students, supervisor of more than 22 PhD students.

MANAGERIAL ACTIVITIES IN SCIENTIFIC BOARDS:

• Board of Slovak Government for Science and Technology (member)
• Advisor for science to Prime minister of Slovakia and minister for education
• Member of the Committee for Science and Technology of the Ministry of Education SR
• Member of the Committee for Biotechnplogy and Biomedicine of the Ministry of Education
• Chairman of the Committee of Minister for coordination of PhD. studies
• Member of Scientific Board of Faculty of Medicine, Comenius University, Bratislava.
• Member of Scientific Board of Faculty of Medicine, Comenius University, Martin
• Member of Scientific Board of University of Constatinus Phylosofer, Nitra
• Member of Scientific Board of Slovak Medical University, Bratislava
• Member of Scientific Board of Slovak Institute of Cardiovascular Diseases, Bratislava
• Member of Scientific Board of ITVS, Comenius University, Bratislava
• Council member of ALLEA (All European Academies – UK)
• Member of European Academy of Sciences and Arts, Austria
• Member of Slovak Academical Society
• Member of the Learned Society of Slovak Academy of Sciences
• Fellow of International Academy of Carsdiovascular Sciences (IACS)
• Member of Board of Directors of IACS
• Member of Advisory Board of IACS
• Foreign member of Russian Academy of Natural Sciences
• Member of Acreditation Board of the Czech Government and Ministry of Education of Czech Rep., Etc…
• Invited symposia speaker for national and international meetings (46x).
• Acting as a session chairman in a number of international and national scientific meetings (48).
• Organizer and president of 23 international Conferences and Symposia.
• Founder and President of Slovak League for Prevention of Cardiovascular Diseases – HEART TO HEART League
• Faunding member of Slovak Society of Electron Microscopical Society
• Faunder and President of Slovak Histo and Cytochemical Society
• Awards: more than 57 national and foreign awards.